New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket

The capsaicin receptor TRPV1 is an outstanding representative of ligand-gated ion channels in ligand selectivity and sensitivity. However, molecular interactions that stabilize the ligand-binding pocket in its permissive conformation, and how many permissive conformations the ligand-binding pocket m...

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Detalles Bibliográficos
Autores principales: Vu, Simon, Singh, Vikrant, Wulff, Heike, Yarov-Yarovoy, Vladimir, Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671684/
https://www.ncbi.nlm.nih.gov/pubmed/33164749
http://dx.doi.org/10.7554/eLife.62039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671684/
https://www.ncbi.nlm.nih.gov/pubmed/33164749
http://dx.doi.org/10.7554/eLife.62039

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