Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not known. Here we demonstrate that all tested class II IN...

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Detalles Bibliográficos
Autores principales: Elliott, Jennifer L, Eschbach, Jenna E, Koneru, Pratibha C, Li, Wen, Puray-Chavez, Maritza, Townsend, Dana, Lawson, Dana Q, Engelman, Alan N, Kvaratskhelia, Mamuka, Kutluay, Sebla B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671690/
https://www.ncbi.nlm.nih.gov/pubmed/32960169
http://dx.doi.org/10.7554/eLife.54311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671690/
https://www.ncbi.nlm.nih.gov/pubmed/32960169
http://dx.doi.org/10.7554/eLife.54311

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