Activation of Cytosolic Calpain, Not Caspase, Is Underlying Mechanism for Hypoxic RGC Damage in Human Retinal Explants

PURPOSE: Activation of proteolytic enzymes, calpains and caspases, have been observed in many models of retinal disease. We previously demonstrated calpain activation in monkey retinal explants cultured under hypoxia. However, cellular responses are often species-specific. The purpose of the present...

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Detalles Bibliográficos
Autores principales: Kobayashi-Otsugu, Momoko, Orihara, Kana, Nakajima, Emi, Shearer, Thomas R., Azuma, Mitsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671854/
https://www.ncbi.nlm.nih.gov/pubmed/33156340
http://dx.doi.org/10.1167/iovs.61.13.13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671854/
https://www.ncbi.nlm.nih.gov/pubmed/33156340
http://dx.doi.org/10.1167/iovs.61.13.13

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