The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif

Endocytosis of the amyloid precursor protein (APP) is critical for generation of β-amyloid, aggregating in Alzheimer's disease. APP endocytosis depending on the intracellular NPTY motif is well investigated, whereas involvement of the YTSI (also termed BaSS) motif remains controversial. Here, w...

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Detalles Bibliográficos
Autores principales: Eggert, Simone, Gruebl, Tomas, Rajender, Ritu, Rupp, Carsten, Sander, Bianca, Heesch, Amelie, Zimmermann, Marius, Hoepfner, Sebastian, Zentgraf, Hanswalter, Kins, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671991/
https://www.ncbi.nlm.nih.gov/pubmed/32065241
http://dx.doi.org/10.1007/s00018-020-03467-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671991/
https://www.ncbi.nlm.nih.gov/pubmed/32065241
http://dx.doi.org/10.1007/s00018-020-03467-1

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