The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif

Endocytosis of the amyloid precursor protein (APP) is critical for generation of β-amyloid, aggregating in Alzheimer's disease. APP endocytosis depending on the intracellular NPTY motif is well investigated, whereas involvement of the YTSI (also termed BaSS) motif remains controversial. Here, w...

Descripción completa

Detalles Bibliográficos
Autores principales: Eggert, Simone, Gruebl, Tomas, Rajender, Ritu, Rupp, Carsten, Sander, Bianca, Heesch, Amelie, Zimmermann, Marius, Hoepfner, Sebastian, Zentgraf, Hanswalter, Kins, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671991/
https://www.ncbi.nlm.nih.gov/pubmed/32065241
http://dx.doi.org/10.1007/s00018-020-03467-1

Ejemplares similares

Ejemplares similares