Cargando…

The Active Constituent From Gynostemma Pentaphyllum Prevents Liver Fibrosis Through Regulation of the TGF-β1/NDRG2/MAPK Axis

Liver fibrosis resulting from chronic liver damage constitutes a major health care burden worldwide; however, no antifibrogenic agents are currently available. Our previous study reported that the small molecule NPLC0393 extracted from the herb Gynostemma pentaphyllum exerts efficient antifibrotic e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Hui, Wang, Kuifeng, Liu, Qian, Ji, Feihong, Zhou, Hu, Fang, Shanhua, Zhu, Jiansheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672159/ https://www.ncbi.nlm.nih.gov/pubmed/33329740 http://dx.doi.org/10.3389/fgene.2020.594824

Ejemplares similares

The Effect of Gynostemma pentaphyllum Extract on Mouse Dermal Fibroblasts
por: Lobo, Sara Nadia, et al.
Publicado: (2014)

New Dammarane-Type Saponins from Gynostemma pentaphyllum
por: Chen, Po-Yen, et al.
Publicado: (2019)

Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)
por: Li, Yantao, et al.
Publicado: (2016)

Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation
por: Keilhoff, Gerburg, et al.
Publicado: (2017)

Complete chloroplast genome sequence of the medicinal plant Gynostemma pentaphyllum
por: Zeng, Xin-Yi, et al.
Publicado: (2016)

Transcriptome Sequencing of Gynostemma pentaphyllum to Identify Genes and Enzymes Involved in Triterpenoid Biosynthesis
por: Chen, Qicong, et al.
Publicado: (2016)

Metabonomics Study of the Therapeutic Mechanism of Gynostemma pentaphyllum and Atorvastatin for Hyperlipidemia in Rats
por: Wang, Miao, et al.
Publicado: (2013)

Restoration of Electric Footshock-Induced Immunosuppression in Mice by Gynostemma pentaphyllum Components
por: Im, Sun-A, et al.
Publicado: (2012)

Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum
por: Liao, Weilin, et al.
Publicado: (2020)

Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum
por: Su, Chao, et al.
Publicado: (2021)

Gynostemma pentaphyllum for dyslipidemia: A systematic review of randomized controlled trials
por: Dai, Ning, et al.
Publicado: (2022)

Transcriptomics and metabolomics association analysis revealed the responses of Gynostemma pentaphyllum to cadmium
por: Zhou, Yunyi, et al.
Publicado: (2023)

Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients
por: Huyen, V. T. T., et al.
Publicado: (2013)

Hybrid sequencing of the Gynostemma pentaphyllum transcriptome provides new insights into gypenoside biosynthesis
por: Liang, Tongtong, et al.
Publicado: (2019)

Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice
por: Shang, Xiaoya, et al.
Publicado: (2016)

Chromosome-level genome assembly of Gynostemma pentaphyllum provides insights into gypenoside biosynthesis
por: Huang, Ding, et al.
Publicado: (2021)

Activity Components from Gynostemma pentaphyllum for Preventing Hepatic Fibrosis and of Its Molecular Targets by Network Pharmacology Approach
por: Zhang, Yumeng, et al.
Publicado: (2021)

Chemical Constituents, Antioxidant, and α-Glucosidase Inhibitory Activities of Different Fermented Gynostemma Pentaphyllum Leaves and Untargeted Metabolomic Measurement of the Metabolite Variation
por: Zhang, Xuechun, et al.
Publicado: (2023)

In Vitro Anticancer Activity of a Nonpolar Fraction from Gynostemma pentaphyllum (Thunb.) Makino
por: Li, Yantao, et al.
Publicado: (2016)

Isolation, Structures, and Bioactivities of the Polysaccharides from Gynostemma pentaphyllum (Thunb.) Makino: A Review
por: Ji, Xiaolong, et al.
Publicado: (2018)

Caco-2 Cell Permeability of Flavonoids and Saponins from Gynostemma pentaphyllum: the Immortal Herb
por: Ahmed, Iftekhar, et al.
Publicado: (2020)

Complete chloroplast genome sequence of Gynostemma pentaphyllum (Cucurbitaceae), a perennial medicinal herb
por: Shi, Yancai, et al.
Publicado: (2019)

Network pharmacology analysis reveals neuroprotection of Gynostemma pentaphyllum (Thunb.) Makino in Alzheimer’ disease
por: Wang, Jiahao, et al.
Publicado: (2022)

Effect of Polysaccharide Extracted From Gynostemma Pentaphyllum on the Body Weight and Gut Microbiota of Mice
por: Li, Shiwei, et al.
Publicado: (2022)

Molecular Mechanisms of Gynostemma pentaphyllum in Prevention and Treatment of Non-Small-Cell Lung Cancer
por: Liang, Renji, et al.
Publicado: (2022)

The Content and Principle of the Rare Ginsenosides Produced from Gynostemma pentaphyllum after Heat Treatment
por: Li, Xin-Can, et al.
Publicado: (2023)

Gynostemma Pentaphyllum Increases Exercise Performance and Alters Mitochondrial Respiration and AMPK in Healthy Males
por: Nayyar, Deepti, et al.
Publicado: (2023)

Chemical composition of tetraploid Gynostemma pentaphyllum gypenosides and their suppression on inflammatory response by NF‐κB/MAPKs/AP‐1 signaling pathways
por: Wang, Bo, et al.
Publicado: (2020)

Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients
por: Huyen, V. T. T., et al.
Publicado: (2012)

Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release
por: Lokman, Ezarul Faradianna, et al.
Publicado: (2015)

Population genetic structure, migration, and polyploidy origin of a medicinal species Gynostemma pentaphyllum (Cucurbitaceae)
por: Zhang, Xiao, et al.
Publicado: (2019)

Bioassay-guided isolation and identification of anticancer and antioxidant compounds from Gynostemma pentaphyllum (Thunb.) Makino
por: Wang, Tian-Xing, et al.
Publicado: (2018)

Structural modulation of gut microbiota during alleviation of non-alcoholic fatty liver disease with Gynostemma pentaphyllum in rats
por: Shen, Shu-Hua, et al.
Publicado: (2020)

Mechanisms of Gynostemma pentaphyllum against non‐alcoholic fibre liver disease based on network pharmacology and molecular docking
por: Wang, Cunzhi, et al.
Publicado: (2022)

Anxiolytic Effects of Herbal Ethanol Extract from Gynostemma pentaphyllum in Mice after Exposure to Chronic Stress
por: Choi, Hyun Sook, et al.
Publicado: (2013)

Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice
por: Mastinu, Andrea, et al.
Publicado: (2021)

Effects of Plant Elicitors on Growth and Gypenosides Biosynthesis in Cell Culture of Giao co lam (Gynostemma pentaphyllum)
por: Quang, Hoang Tan, et al.
Publicado: (2022)

Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay
por: Hong, Ming, et al.
Publicado: (2018)

TGF-β1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM
por: Wang, Kuifeng, et al.
Publicado: (2019)

Herbal Extract of Gynostemma Pentaphyllum Decreases Hepatic Glucose Output in Type 2 Diabetic Goto-Kakizaki Rats
por: Yassin, K., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_e7ql1h8ihtshamat9u9vogcmq4