Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging

BACKGROUND & AIMS: Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and neuromodulator cells interstitial cells of Cajal (ICC) decline with age in humans, and their loss contributes to gastric dysfunction in progeric klotho mice hy...

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Detalles Bibliográficos
Autores principales: Hayashi, Yujiro, Asuzu, David T., Bardsley, Michael R., Gajdos, Gabriella B., Kvasha, Sergiy M., Linden, David R., Nagy, Rea A., Saravanaperumal, Siva Arumugam, Syed, Sabriya A., Toyomasu, Yoshitaka, Yan, Huihuang, Chini, Eduardo N., Gibbons, Simon J., Kellogg, Todd A., Khazaie, Khashayarsha, Kuro-o, Makoto, Machado Espindola Netto, Jair, Singh, Mahendra Pal, Tidball, James G., Wehling-Henricks, Michelle, Farrugia, Gianrico, Ordog, Tamas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672319/
https://www.ncbi.nlm.nih.gov/pubmed/32771388
http://dx.doi.org/10.1016/j.jcmgh.2020.07.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672319/
https://www.ncbi.nlm.nih.gov/pubmed/32771388
http://dx.doi.org/10.1016/j.jcmgh.2020.07.011

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