BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers

A single G-quadruplex forming sequence from the human telomere can adopt six distinct topologies that are inter-convertible under physiological conditions. This presents challenges to design ligands that show selectivity and specificity towards a particular conformation. Additional complexity is int...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Chao, Liu, Zhu, Hou, Haitao, Ding, Jieqin, Chen, Xin, Xie, Congbao, Song, Zibing, Hu, Zhe, Feng, Mingqian, Mohamed, Hany I, Xu, Shengzhen, Parkinson, Gary N, Haider, Shozeb, Wei, Dengguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672424/
https://www.ncbi.nlm.nih.gov/pubmed/33080032
http://dx.doi.org/10.1093/nar/gkaa870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672424/
https://www.ncbi.nlm.nih.gov/pubmed/33080032
http://dx.doi.org/10.1093/nar/gkaa870

Ejemplares similares