Visualization of uracils created by APOBEC3A using UdgX shows colocalization with RPA at stalled replication forks

The AID/APOBEC enzymes deaminate cytosines in single-stranded DNA (ssDNA) and play key roles in innate and adaptive immunity. The resulting uracils cause mutations and strand breaks that inactivate viruses and diversify antibody repertoire. Mutational evidence suggests that two members of this famil...

Descripción completa

Detalles Bibliográficos
Autores principales: Stewart, Jessica A, Schauer, Grant, Bhagwat, Ashok S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672425/
https://www.ncbi.nlm.nih.gov/pubmed/33074285
http://dx.doi.org/10.1093/nar/gkaa845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672425/
https://www.ncbi.nlm.nih.gov/pubmed/33074285
http://dx.doi.org/10.1093/nar/gkaa845

Ejemplares similares