Viral RNA recognition by LGP2 and MDA5, and activation of signaling through step-by-step conformational changes

Cytoplasmic RIG-I-like receptor (RLR) proteins in mammalian cells recognize viral RNA and initiate an antiviral response that results in IFN-β induction. Melanoma differentiation-associated protein 5 (MDA5) forms fibers along viral dsRNA and propagates an antiviral response via a signaling domain, t...

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Detalles Bibliográficos
Autores principales: Duic, Ivana, Tadakuma, Hisashi, Harada, Yoshie, Yamaue, Ryo, Deguchi, Katashi, Suzuki, Yuki, Yoshimura, Shige H, Kato, Hiroki, Takeyasu, Kunio, Fujita, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672446/
https://www.ncbi.nlm.nih.gov/pubmed/33137199
http://dx.doi.org/10.1093/nar/gkaa935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672446/
https://www.ncbi.nlm.nih.gov/pubmed/33137199
http://dx.doi.org/10.1093/nar/gkaa935

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