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Alignment and quantification of ChIP-exo crosslinking patterns reveal the spatial organization of protein–DNA complexes
The ChIP-exo assay precisely delineates protein–DNA crosslinking patterns by combining chromatin immunoprecipitation with 5′ to 3′ exonuclease digestion. Within a regulatory complex, the physical distance of a regulatory protein to DNA affects crosslinking efficiencies. Therefore, the spatial organi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672471/ https://www.ncbi.nlm.nih.gov/pubmed/32747934 http://dx.doi.org/10.1093/nar/gkaa618 |