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Alignment and quantification of ChIP-exo crosslinking patterns reveal the spatial organization of protein–DNA complexes

The ChIP-exo assay precisely delineates protein–DNA crosslinking patterns by combining chromatin immunoprecipitation with 5′ to 3′ exonuclease digestion. Within a regulatory complex, the physical distance of a regulatory protein to DNA affects crosslinking efficiencies. Therefore, the spatial organi...

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Detalles Bibliográficos
Autores principales:	Yamada, Naomi, Rossi, Matthew J, Farrell, Nina, Pugh, B Franklin, Mahony, Shaun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	NAR Breakthrough Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672471/ https://www.ncbi.nlm.nih.gov/pubmed/32747934 http://dx.doi.org/10.1093/nar/gkaa618

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