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Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase
DNA methyltransferases interact with their CpG target sites in the context of variable flanking sequences. We investigated DNA methylation by the human DNMT3B catalytic domain using substrate pools containing CpX target sites in randomized flanking context and identified combined effects of CpG reco...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672481/ https://www.ncbi.nlm.nih.gov/pubmed/33105482 http://dx.doi.org/10.1093/nar/gkaa938 |