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Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase

DNA methyltransferases interact with their CpG target sites in the context of variable flanking sequences. We investigated DNA methylation by the human DNMT3B catalytic domain using substrate pools containing CpX target sites in randomized flanking context and identified combined effects of CpG reco...

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Detalles Bibliográficos
Autores principales:	Dukatz, Michael, Adam, Sabrina, Biswal, Mahamaya, Song, Jikui, Bashtrykov, Pavel, Jeltsch, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672481/ https://www.ncbi.nlm.nih.gov/pubmed/33105482 http://dx.doi.org/10.1093/nar/gkaa938

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