Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells

Selective inhibition of histone deacetylase 3 (HDAC3) prevents glucolipotoxicity-induced β-cell dysfunction and apoptosis by alleviation of proapoptotic endoplasmic reticulum (ER) stress-signaling, but the precise molecular mechanisms of alleviation are unexplored. By unbiased microarray analysis of...

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Detalles Bibliográficos
Autores principales: Dahlby, Tina, Simon, Christian, Backe, Marie Balslev, Dahllöf, Mattias Salling, Holson, Edward, Wagner, Bridget K., Böni-Schnetzler, Marianne, Marzec, Michal Tomasz, Lundh, Morten, Mandrup-Poulsen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672588/
https://www.ncbi.nlm.nih.gov/pubmed/33137873
http://dx.doi.org/10.3390/ijms21218016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672588/
https://www.ncbi.nlm.nih.gov/pubmed/33137873
http://dx.doi.org/10.3390/ijms21218016

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