ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia

BACKGROUND: Characterized by abnormal lung growth or maturation, congenital diaphragmatic hernia (CDH) affects 1:3000 live births. Cellular studies report proximal (SOX2(+)) and distal (SOX9(+)) progenitor cells as key modulators of branching morphogenesis and epithelial differentiation, whereas tra...

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Detalles Bibliográficos
Autores principales: Gonçalves, Ana N., Correia-Pinto, Jorge, Nogueira-Silva, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672875/
https://www.ncbi.nlm.nih.gov/pubmed/33208157
http://dx.doi.org/10.1186/s12931-020-01568-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672875/
https://www.ncbi.nlm.nih.gov/pubmed/33208157
http://dx.doi.org/10.1186/s12931-020-01568-w

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