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ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia
BACKGROUND: Characterized by abnormal lung growth or maturation, congenital diaphragmatic hernia (CDH) affects 1:3000 live births. Cellular studies report proximal (SOX2(+)) and distal (SOX9(+)) progenitor cells as key modulators of branching morphogenesis and epithelial differentiation, whereas tra...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672875/ https://www.ncbi.nlm.nih.gov/pubmed/33208157 http://dx.doi.org/10.1186/s12931-020-01568-w |