Cargando…

Inhibition of pyruvate dehydrogenase kinase influence microbiota and metabolomic profile in pancreatic cancer xenograft mice

OBJECTIVE: Despite recent advances in treatment options, pancreatic cancer remains the most deadly major cancer. Targeting metabolism represents an emerging anti-cancer strategy. RESULTS: Metagenomic 16S analysis was employed to explore the effect of Dichloroacetate (DCA) on the composition of the f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adamberg, Kaarel, Vilu, Raivo, Pazienza, Valerio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672971/ https://www.ncbi.nlm.nih.gov/pubmed/33208188 http://dx.doi.org/10.1186/s13104-020-05384-9

Ejemplares similares

Engineered Resistant-Starch (ERS) Diet Shapes Colon Microbiota Profile in Parallel with the Retardation of Tumor Growth in In Vitro and In Vivo Pancreatic Cancer Models
por: Panebianco, Concetta, et al.
Publicado: (2017)

Decrease of energy spilling in Escherichia coli continuous cultures with rising specific growth rate and carbon wasting
por: Valgepea, Kaspar, et al.
Publicado: (2011)

Increased Biomass Yield of Lactococcus lactis by Reduced Overconsumption of Amino Acids and Increased Catalytic Activities of Enzymes
por: Adamberg, Kaarel, et al.
Publicado: (2012)

Lean-Proteome Strains – Next Step in Metabolic Engineering
por: Valgepea, Kaspar, et al.
Publicado: (2015)

Systems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase
por: Valgepea, Kaspar, et al.
Publicado: (2010)

Multi-omics approach to study the growth efficiency and amino acid metabolism in Lactococcus lactis at various specific growth rates
por: Lahtvee, Petri-Jaan, et al.
Publicado: (2011)

Microcalorimetric study of the growth of Streptococcus thermophilus in renneted milk
por: Stulova, Irina, et al.
Publicado: (2015)

High Levels of Prebiotic Resistant Starch in Diet Modulate Gene Expression and Metabolomic Profile in Pancreatic Cancer Xenograft Mice
por: Panebianco, Concetta, et al.
Publicado: (2019)

Self-reproduction and doubling time limits of different cellular subsystems
por: Abner, Kristo, et al.
Publicado: (2023)

Use of Changestat for Growth Rate Studies of Gut Microbiota
por: Adamberg, Kaarel, et al.
Publicado: (2020)

Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
por: Honda, Kazuhisa, et al.
Publicado: (2017)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Genetic Perturbation of Pyruvate Dehydrogenase Kinase 1 Modulates Growth, Angiogenesis and Metabolic Pathways in Ovarian Cancer Xenografts
por: Venturoli, Carolina, et al.
Publicado: (2021)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

Levan Enhances Associated Growth of Bacteroides, Escherichia, Streptococcus and Faecalibacterium in Fecal Microbiota
por: Adamberg, Kaarel, et al.
Publicado: (2015)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
por: Jeoung, Nam Ho
Publicado: (2015)

Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
por: Larrieu, Claire M., et al.
Publicado: (2022)

Low‐carbohydrate high‐fat weight reduction diet induces changes in human gut microbiota
por: Jaagura, Madis, et al.
Publicado: (2021)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
por: Sutendra, Gopinath, et al.
Publicado: (2013)

Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
por: Jung, Gwon-Soo, et al.
Publicado: (2016)

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
por: Wang, Xiuxiu, et al.
Publicado: (2021)

Tuning gut microbiota through a probiotic blend in gemcitabine‐treated pancreatic cancer xenografted mice
por: Panebianco, Concetta, et al.
Publicado: (2021)

Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome
por: Mohammad, Goran Hamid, et al.
Publicado: (2016)

Pyruvate dehydrogenase complex integrates the metabolome and epigenome in memory T cell differentiation in vitro
por: Tarasenko, Tatiana N., et al.
Publicado: (2023)

Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer
por: Mohammad, Goran Hamid, et al.
Publicado: (2019)

Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
por: Jeoung, Nam Ho, et al.
Publicado: (2010)

Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas
por: Jha, Mithilesh Kumar, et al.
Publicado: (2013)

Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
por: Zhou, Xiaoli, et al.
Publicado: (2016)

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
por: Leem, Jaechan, et al.
Publicado: (2016)

Global view of cognate kinase activation by the human pyruvate dehydrogenase complex
por: Guevara, Elena L., et al.
Publicado: (2017)

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases
por: Jane, Esther P., et al.
Publicado: (2021)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

Ketogenic diet in action: Metabolic profiling of pyruvate dehydrogenase deficiency
por: Ogawa, Eri, et al.
Publicado: (2023)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
por: Park, Sungmi, et al.
Publicado: (2018)

Impact of Different Types of Diet on Gut Microbiota Profiles and Cancer Prevention and Treatment
por: Klement, Rainer J., et al.
Publicado: (2019)

Metabolomic analysis of Drosophila melanogaster larvae lacking Pyruvate kinase
por: Heidarian, Yasaman, et al.
Publicado: (2023)

Pyruvate Dehydrogenase Kinase 4: Regulation by Thiazolidinediones and Implication in Glyceroneogenesis in Adipose Tissue
por: Cadoudal, Thomas, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_68cdkt5b010cp9fsmtauhcvb8q