Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination

Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Shuo, Yuan, Bo, Cao, Jixin, Chen, Jingqi, Chen, Jinlong, Qiu, Jiayi, Zhao, Xing-Ming, Wang, Xiaolin, Qiu, Zilong, Cheng, Tian-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673026/
https://www.ncbi.nlm.nih.gov/pubmed/33203850
http://dx.doi.org/10.1038/s41467-020-19730-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673026/
https://www.ncbi.nlm.nih.gov/pubmed/33203850
http://dx.doi.org/10.1038/s41467-020-19730-9

Ejemplares similares