Specific decreasing of Na(+) channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome

Reduced cardiac sodium (Na(+)) channel current (I(Na)) resulting from the loss-of-function of Na(+) channel is a major cause of lethal arrhythmias in Brugada syndrome (BrS). Inspired by previous experimental studies which showed that in heart diseases I(Na) was reduced along with expression changes...

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Detalles Bibliográficos
Autores principales: Tsumoto, Kunichika, Ashihara, Takashi, Naito, Narumi, Shimamoto, Takao, Amano, Akira, Kurata, Yasutaka, Kurachi, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673036/
https://www.ncbi.nlm.nih.gov/pubmed/33203944
http://dx.doi.org/10.1038/s41598-020-76681-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673036/
https://www.ncbi.nlm.nih.gov/pubmed/33203944
http://dx.doi.org/10.1038/s41598-020-76681-3

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