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Specific decreasing of Na(+) channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome
Reduced cardiac sodium (Na(+)) channel current (I(Na)) resulting from the loss-of-function of Na(+) channel is a major cause of lethal arrhythmias in Brugada syndrome (BrS). Inspired by previous experimental studies which showed that in heart diseases I(Na) was reduced along with expression changes...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673036/ https://www.ncbi.nlm.nih.gov/pubmed/33203944 http://dx.doi.org/10.1038/s41598-020-76681-3 |