Raloxifene prevents stress granule dissolution, impairs translational control and promotes cell death during hypoxia in glioblastoma cells

Glioblastoma (GBM) is the most common primary malignant brain tumor, and it has a uniformly poor prognosis. Hypoxia is a feature of the GBM microenvironment, and previous work has shown that cancer cells residing in hypoxic regions resist treatment. Hypoxia can trigger the formation of stress granul...

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Detalles Bibliográficos
Autores principales: Attwood, Kathleen M., Robichaud, Aaron, Westhaver, Lauren P., Castle, Elizabeth L., Brandman, David M., Balgi, Aruna D., Roberge, Michel, Colp, Patricia, Croul, Sidney, Kim, Inhwa, McCormick, Craig, Corcoran, Jennifer A., Weeks, Adrienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673037/
https://www.ncbi.nlm.nih.gov/pubmed/33203845
http://dx.doi.org/10.1038/s41419-020-03159-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673037/
https://www.ncbi.nlm.nih.gov/pubmed/33203845
http://dx.doi.org/10.1038/s41419-020-03159-5

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