Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function

Methamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy and defined the molecular mechanisms using autopsy samples of human hearts, and a mouse model of “bing...

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Detalles Bibliográficos
Autores principales: Abdullah, Chowdhury S., Aishwarya, Richa, Alam, Shafiul, Morshed, Mahboob, Remex, Naznin Sultana, Nitu, Sadia, Kolluru, Gopi K., Traylor, James, Miriyala, Sumitra, Panchatcharam, Manikandan, Hartman, Brandon, King, Judy, Bhuiyan, Mohammad Alfrad Nobel, Chandran, Sunitha, Woolard, Matthew D., Yu, Xiuping, Goeders, Nicholas E., Dominic, Paari, Arnold, Connie L., Stokes, Karen, Kevil, Christopher G., Orr, A. Wayne, Bhuiyan, Md. Shenuarin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673131/
https://www.ncbi.nlm.nih.gov/pubmed/33203971
http://dx.doi.org/10.1038/s42003-020-01408-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673131/
https://www.ncbi.nlm.nih.gov/pubmed/33203971
http://dx.doi.org/10.1038/s42003-020-01408-z

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