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Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial-mesenchymal transition in the valvular damage due to rheumatic heart disease

Rheumatic heart disease (RHD) is an autoimmune disease caused by rheumatic fever following group A hemolytic streptococcal infection and primarily affects the mitral valve. RHD is currently a major global health problem. However, the exact pathological mechanisms associated with RHD-induced cardiac...

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Detalles Bibliográficos
Autores principales: Xian, Shenglin, Chen, Ang, Wu, Xiaodan, Lu, Chuanghong, Wu, Yunjiao, Huang, Feng, Zeng, Zhiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673319/
https://www.ncbi.nlm.nih.gov/pubmed/33179113
http://dx.doi.org/10.3892/mmr.2020.11648