MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis

Cancer cells are dysregulated and addicted to continuous supply and metabolism of nutritional glucose and amino acids (e.g., arginine) to drive the synthesis of critical macromolecules for uncontrolled growth. Recent studies have revealed that genome-derived microRNA (miRNA or miR)-1291-5p (miR-1291...

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Detalles Bibliográficos
Autores principales: Tu, Mei-Juan, Duan, Zhijian, Liu, Zhenzhen, Zhang, Chao, Bold, Richard J., Gonzalez, Frank J., Kim, Edward J., Yu, Ai-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673485/
https://www.ncbi.nlm.nih.gov/pubmed/33051382
http://dx.doi.org/10.1124/molpharm.120.000130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673485/
https://www.ncbi.nlm.nih.gov/pubmed/33051382
http://dx.doi.org/10.1124/molpharm.120.000130

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