LRRK2 mediates tubulation and vesicle sorting from lysosomes

Genetic variation around the LRRK2 gene affects risk of both familial and sporadic Parkinson’s disease (PD). However, the biological functions of LRRK2 remain incompletely understood. Here, we report that LRRK2 is recruited to lysosomes after exposure of cells to the lysosome membrane–rupturing agen...

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Detalles Bibliográficos
Autores principales: Bonet-Ponce, Luis, Beilina, Alexandra, Williamson, Chad D., Lindberg, Eric, Kluss, Jillian H., Saez-Atienzar, Sara, Landeck, Natalie, Kumaran, Ravindran, Mamais, Adamantios, Bleck, Christopher K. E., Li, Yan, Cookson, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673727/
https://www.ncbi.nlm.nih.gov/pubmed/33177079
http://dx.doi.org/10.1126/sciadv.abb2454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673727/
https://www.ncbi.nlm.nih.gov/pubmed/33177079
http://dx.doi.org/10.1126/sciadv.abb2454

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