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LRRK2 mediates tubulation and vesicle sorting from lysosomes
Genetic variation around the LRRK2 gene affects risk of both familial and sporadic Parkinson’s disease (PD). However, the biological functions of LRRK2 remain incompletely understood. Here, we report that LRRK2 is recruited to lysosomes after exposure of cells to the lysosome membrane–rupturing agen...
Autores principales: | Bonet-Ponce, Luis, Beilina, Alexandra, Williamson, Chad D., Lindberg, Eric, Kluss, Jillian H., Saez-Atienzar, Sara, Landeck, Natalie, Kumaran, Ravindran, Mamais, Adamantios, Bleck, Christopher K. E., Li, Yan, Cookson, Mark R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673727/ https://www.ncbi.nlm.nih.gov/pubmed/33177079 http://dx.doi.org/10.1126/sciadv.abb2454 |
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