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TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles

Endolysosomes are dynamic, intracellular compartments, regulating their surface-to-volume ratios to counteract membrane swelling or shrinkage caused by osmotic challenges upon tubulation and vesiculation events. While osmosensitivity has been extensively described on the plasma membrane, the mechani...

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Detalles Bibliográficos
Autores principales: Chen, Cheng-Chang, Krogsaeter, Einar, Butz, Elisabeth S., Li, Yanfen, Puertollano, Rosa, Wahl-Schott, Christian, Biel, Martin, Grimm, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673730/
https://www.ncbi.nlm.nih.gov/pubmed/33177082
http://dx.doi.org/10.1126/sciadv.abb5064