HSF1 physically neutralizes amyloid oligomers to empower overgrowth and bestow neuroprotection

The role of proteomic instability in cancer, particularly amyloidogenesis, remains obscure. Heat shock factor 1 (HSF1) transcriptionally governs the proteotoxic stress response to suppress proteomic instability and enhance survival. Paradoxically, HSF1 promotes oncogenesis. Here, we report that AKT...

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Detalles Bibliográficos
Autores principales: Tang, Zijian, Su, Kuo-Hui, Xu, Meng, Dai, Chengkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673739/
https://www.ncbi.nlm.nih.gov/pubmed/33177089
http://dx.doi.org/10.1126/sciadv.abc6871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673739/
https://www.ncbi.nlm.nih.gov/pubmed/33177089
http://dx.doi.org/10.1126/sciadv.abc6871

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