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HSF1 physically neutralizes amyloid oligomers to empower overgrowth and bestow neuroprotection

The role of proteomic instability in cancer, particularly amyloidogenesis, remains obscure. Heat shock factor 1 (HSF1) transcriptionally governs the proteotoxic stress response to suppress proteomic instability and enhance survival. Paradoxically, HSF1 promotes oncogenesis. Here, we report that AKT...

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Detalles Bibliográficos
Autores principales:	Tang, Zijian, Su, Kuo-Hui, Xu, Meng, Dai, Chengkai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673739/ https://www.ncbi.nlm.nih.gov/pubmed/33177089 http://dx.doi.org/10.1126/sciadv.abc6871

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