A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation

Topoisomerases form transient covalent DNA cleavage complexes to perform their reactions. Topoisomerase I cleavage complexes (TOP1ccs) are trapped by camptothecin and TOP2ccs by etoposide. Proteolysis of the trapped topoisomerase DNA-protein cross-links (TOP-DPCs) is a key step for some pathways to...

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Detalles Bibliográficos
Autores principales: Sun, Yilun, Miller Jenkins, Lisa M., Su, Yijun P., Nitiss, Karin C., Nitiss, John L., Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673754/
https://www.ncbi.nlm.nih.gov/pubmed/33188014
http://dx.doi.org/10.1126/sciadv.aba6290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673754/
https://www.ncbi.nlm.nih.gov/pubmed/33188014
http://dx.doi.org/10.1126/sciadv.aba6290

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