Dedifferentiation and neuronal repression define familial Alzheimer’s disease

Identifying the systems-level mechanisms that lead to Alzheimer’s disease, an unmet need, is an essential step toward the development of therapeutics. In this work, we report that the key disease-causative mechanisms, including dedifferentiation and repression of neuronal identity, are triggered by...

Descripción completa

Detalles Bibliográficos
Autores principales: Caldwell, Andrew B., Liu, Qing, Schroth, Gary P., Galasko, Douglas R., Yuan, Shauna H., Wagner, Steven L., Subramaniam, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673760/
https://www.ncbi.nlm.nih.gov/pubmed/33188013
http://dx.doi.org/10.1126/sciadv.aba5933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673760/
https://www.ncbi.nlm.nih.gov/pubmed/33188013
http://dx.doi.org/10.1126/sciadv.aba5933

Ejemplares similares