Na(+)-dependent gate dynamics and electrostatic attraction ensure substrate coupling in glutamate transporters

Excitatory amino acid transporters (EAATs) harness [Na(+)], [K(+)], and [H(+)] gradients for fast and efficient glutamate removal from the synaptic cleft. Since each glutamate is cotransported with three Na(+) ions, [Na(+)] gradients are the predominant driving force for glutamate uptake. We combine...

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Detalles Bibliográficos
Autores principales: Alleva, C., Kovalev, K., Astashkin, R., Berndt, M. I., Baeken, C., Balandin, T., Gordeliy, V., Fahlke, Ch., Machtens, J.-P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673805/
https://www.ncbi.nlm.nih.gov/pubmed/33208356
http://dx.doi.org/10.1126/sciadv.aba9854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673805/
https://www.ncbi.nlm.nih.gov/pubmed/33208356
http://dx.doi.org/10.1126/sciadv.aba9854

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