PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

Stalled replication forks can be restarted and repaired by RAD51-mediated homologous recombination (HR), but HR can also perform post-replicative repair after bypass of the obstacle. Bulky DNA adducts are important replication-blocking lesions, but it is unknown whether they activate HR at stalled f...

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Detalles Bibliográficos
Autores principales: Piberger, Ann Liza, Bowry, Akhil, Kelly, Richard D. W., Walker, Alexandra K., González-Acosta, Daniel, Bailey, Laura J., Doherty, Aidan J., Méndez, Juan, Morris, Joanna R., Bryant, Helen E., Petermann, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673990/
https://www.ncbi.nlm.nih.gov/pubmed/33203852
http://dx.doi.org/10.1038/s41467-020-19570-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673990/
https://www.ncbi.nlm.nih.gov/pubmed/33203852
http://dx.doi.org/10.1038/s41467-020-19570-7

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