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PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
Stalled replication forks can be restarted and repaired by RAD51-mediated homologous recombination (HR), but HR can also perform post-replicative repair after bypass of the obstacle. Bulky DNA adducts are important replication-blocking lesions, but it is unknown whether they activate HR at stalled f...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673990/ https://www.ncbi.nlm.nih.gov/pubmed/33203852 http://dx.doi.org/10.1038/s41467-020-19570-7 |