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Computationally predicting clinical drug combination efficacy with cancer cell line screens and independent drug action
Evidence has recently emerged that many clinical cancer drug combinations may derive their efficacy from independent drug action (IDA), where patients only receive benefit from the single most effective drug in a drug combination. Here we present IDACombo, an IDA based method to predict the efficacy...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673995/ https://www.ncbi.nlm.nih.gov/pubmed/33203866 http://dx.doi.org/10.1038/s41467-020-19563-6 |