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Complexities of a protonatable substrate in measurements of Hoechst 33342 transport by multidrug transporter LmrP

Multidrug transporters can confer drug resistance on cells by extruding structurally unrelated compounds from the cellular interior. In transport assays, Hoechst 33342 (referred to as Hoechst) is a commonly used substrate, the fluorescence of which changes in the transport process. With three basic...

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Detalles Bibliográficos
Autores principales:	Swain, Brendan M., Guo, Dawei, Singh, Himansha, Rawlins, Philip B., McAlister, Mark, van Veen, Hendrik W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674423/ https://www.ncbi.nlm.nih.gov/pubmed/33208856 http://dx.doi.org/10.1038/s41598-020-76943-0

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