Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity

Glial cells are early sensors of neuronal injury and can store lipids in lipid droplets under oxidative stress conditions. Here, we investigated the functions of the RNA-binding protein, SPEN/SHARP, in the context of Parkinson’s disease (PD). Using a data-mining approach, we found that SPEN/SHARP is...

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Detalles Bibliográficos
Autores principales: Girard, Victor, Goubard, Valérie, Querenet, Matthieu, Seugnet, Laurent, Pays, Laurent, Nataf, Serge, Dufourd, Eloïse, Cluet, David, Mollereau, Bertrand, Davoust, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674452/
https://www.ncbi.nlm.nih.gov/pubmed/33208773
http://dx.doi.org/10.1038/s41598-020-76891-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674452/
https://www.ncbi.nlm.nih.gov/pubmed/33208773
http://dx.doi.org/10.1038/s41598-020-76891-9

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