PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation

Protein kinase R-like endoplasmic reticulum kinase (PERK) is one of the endoplasmic reticulum (ER) stress sensors. PERK loss-of-function mutations are known to cause Wolcott–Rallison syndrome. This disease is characterized by early-onset diabetes mellitus, skeletal dysplasia, and cardiac valve malfo...

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Detalles Bibliográficos
Autores principales: Shimizu, Takashi, Maruyama, Kazuaki, Kawamura, Takeshi, Urade, Yoshihiro, Wada, Youichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674462/
https://www.ncbi.nlm.nih.gov/pubmed/33208886
http://dx.doi.org/10.1038/s41598-020-77199-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674462/
https://www.ncbi.nlm.nih.gov/pubmed/33208886
http://dx.doi.org/10.1038/s41598-020-77199-4

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