Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina II Neurons

Previous studies have shown that CCL2 (C–C motif chemokine ligand 2) induces chronic pain, but the exact mechanisms are still unknown. Here, we established models to explore the potential mechanisms. Behavioral experiments revealed that an antagonist of extracellular signal-regulated kinase (ERK) in...

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Detalles Bibliográficos
Autores principales: Zhang, Hui, Ma, Sui-Bin, Gao, Yong-Jing, Xing, Jun-Ling, Xian, Hang, Li, Zhen-Zhen, Shen, Shu-Ning, Wu, Sheng-Xi, Luo, Ceng, Xie, Rou-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674543/
https://www.ncbi.nlm.nih.gov/pubmed/32809188
http://dx.doi.org/10.1007/s12264-020-00557-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674543/
https://www.ncbi.nlm.nih.gov/pubmed/32809188
http://dx.doi.org/10.1007/s12264-020-00557-9

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