Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology

BACKGROUND: Frequency of clinically relevant mutations in solid tumors by targeted and whole-exome sequencing is ∼30%. Transcriptome analysis complements detection of actionable gene fusions in advanced cancer patients. Goal of this study was to determine the added value of anchored multiplex PCR (A...

Descripción completa

Detalles Bibliográficos
Autores principales: Beg, Shaham, Bareja, Rohan, Ohara, Kentaro, Eng, Kenneth Wha, Wilkes, David C., Pisapia, David J., Zoughbi, Wael Al, Kudman, Sarah, Zhang, Wei, Rao, Rema, Manohar, Jyothi, Kane, Troy, Sigouros, Michael, Xiang, Jenny Zhaoying, Khani, Francesca, Robinson, Brian D., Faltas, Bishoy M., Sternberg, Cora N., Sboner, Andrea, Beltran, Himisha, Elemento, Olivier, Mosquera, Juan Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674614/
https://www.ncbi.nlm.nih.gov/pubmed/33190043
http://dx.doi.org/10.1016/j.tranon.2020.100944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674614/
https://www.ncbi.nlm.nih.gov/pubmed/33190043
http://dx.doi.org/10.1016/j.tranon.2020.100944

Ejemplares similares