Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations

BACKGROUND: Na(v)1.5 cardiac Na(+) channel mutations can cause arrhythmogenic syndromes. Some of these mutations exert a dominant negative effect on wild-type channels. Recent studies showed that Na(+) channels can dimerize, allowing coupled gating. This leads to the hypothesis that allosteric inter...

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Detalles Bibliográficos
Autores principales: Hichri, Echrak, Selimi, Zoja, Kucera, Jan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674773/
https://www.ncbi.nlm.nih.gov/pubmed/33250780
http://dx.doi.org/10.3389/fphys.2020.589386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674773/
https://www.ncbi.nlm.nih.gov/pubmed/33250780
http://dx.doi.org/10.3389/fphys.2020.589386

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