Cargando…
Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations
BACKGROUND: Na(v)1.5 cardiac Na(+) channel mutations can cause arrhythmogenic syndromes. Some of these mutations exert a dominant negative effect on wild-type channels. Recent studies showed that Na(+) channels can dimerize, allowing coupled gating. This leads to the hypothesis that allosteric inter...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674773/ https://www.ncbi.nlm.nih.gov/pubmed/33250780 http://dx.doi.org/10.3389/fphys.2020.589386 |