Cargando…

Multicellular contractility contributes to the emergence of mesothelioma nodules

Malignant pleural mesothelioma (MPM) has an overall poor prognosis and unsatisfactory treatment options. MPM nodules, protruding into the pleural cavity may have growth and spreading dynamics distinct that of other solid tumors. We demonstrate that multicellular aggregates can develop spontaneously...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tarnoki-Zach, Julia, Stockhammer, Paul, Isai, Dona Greta, Mehes, Elod, Szeder, Balint, Kovacs, Ildiko, Bugyik, Edina, Paku, Sandor, Berger, Walter, Thomas, Sufi Mary, Neufeld, Zoltan, Dome, Balazs, Hegedus, Balazs, Czirok, Andras
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675981/ https://www.ncbi.nlm.nih.gov/pubmed/33208866 http://dx.doi.org/10.1038/s41598-020-76641-x

Ejemplares similares

Matrigel patterning reflects multicellular contractility
por: Méhes, Előd, et al.
Publicado: (2019)

Development and Evaluation of a Human Skin Equivalent in a Semiautomatic Microfluidic Diffusion Chamber
por: Tárnoki-Zách, Júlia, et al.
Publicado: (2021)

Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow
por: Kovacs, Ildiko, et al.
Publicado: (2022)

Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4
por: Mehes, Elod, et al.
Publicado: (2019)

Author Correction: Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4
por: Mehes, Elod, et al.
Publicado: (2020)

Optical-flow based non-invasive analysis of cardiomyocyte contractility
por: Czirok, Andras, et al.
Publicado: (2017)

Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation
por: Pongor, Lőrinc, et al.
Publicado: (2017)

Mechanisms of vascularization in murine models of primary and metastatic tumor growth
por: Bugyik, Edina, et al.
Publicado: (2016)

Role of (myo)fibroblasts in the development of vascular and connective tissue structure of the C38 colorectal cancer in mice
por: Bugyik, Edina, et al.
Publicado: (2018)

Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis
por: Berta, Judit, et al.
Publicado: (2021)

Absence of the Tks4 Scaffold Protein Induces Epithelial-Mesenchymal Transition-Like Changes in Human Colon Cancer Cells
por: Szeder, Bálint, et al.
Publicado: (2019)

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma
por: Laszlo, Viktoria, et al.
Publicado: (2018)

Software tools for cell culture-related 3D printed structures
por: Gulyas, Marton, et al.
Publicado: (2018)

Unmatched Level of Molecular Convergence among Deeply Divergent Complex Multicellular Fungi
por: Merényi, Zsolt, et al.
Publicado: (2020)

The role of Allee effect in modelling post resection recurrence of glioblastoma
por: Neufeld, Zoltan, et al.
Publicado: (2017)

Viscoelastic Properties of ECM-Rich Embryonic Microenvironments
por: Akos, Zsuzsa, et al.
Publicado: (2020)

HDAC Inhibition Induces PD-L1 Expression in a Novel Anaplastic Thyroid Cancer Cell Line
por: Hegedűs, Luca, et al.
Publicado: (2020)

Quantitative Analysis of a Pilot Transwell Barrier Model with Automated Sampling and Mathematical Modeling
por: Tárnoki-Zách, Júlia, et al.
Publicado: (2023)

Comparative genomics reveals the origin of fungal hyphae and multicellularity
por: Kiss, Enikő, et al.
Publicado: (2019)

Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma
por: Klikovits, Thomas, et al.
Publicado: (2017)

Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation
por: Hegedüs, Luca, et al.
Publicado: (2021)

Circulating FGF18 is decreased in pleural mesothelioma but not correlated with disease prognosis
por: Mosleh, Berta, et al.
Publicado: (2023)

Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models
por: Rókusz, András, et al.
Publicado: (2017)

A comparison of sample preparation strategies for biological tissues and subsequent trace element analysis using LA-ICP-MS
por: Bonta, Maximilian, et al.
Publicado: (2016)

From Bench to Bedside: Attempt to Evaluate Repositioning of Drugs in the Treatment of Metastatic Small Cell Lung Cancer (SCLC)
por: Lohinai, Zoltan, et al.
Publicado: (2016)

Molecular profiles of small cell lung cancer subtypes: therapeutic implications
por: Schwendenwein, Anna, et al.
Publicado: (2021)

Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria
por: Weiss, Gregor L., et al.
Publicado: (2022)

Fibulin-3 levels in malignant pleural mesothelioma are associated with prognosis but not diagnosis
por: Kirschner, Michaela B, et al.
Publicado: (2015)

Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors
por: Torok, Szilvia, et al.
Publicado: (2017)

In‐depth proteomic analysis reveals unique subtype‐specific signatures in human small‐cell lung cancer
por: Szeitz, Beáta, et al.
Publicado: (2022)

SPECC1L-deficient primary mouse embryonic palatal mesenchyme cells show speed and directionality defects
por: Goering, Jeremy P., et al.
Publicado: (2021)

Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue
por: Kresin, Nico, et al.
Publicado: (2019)

Enhancer of zeste homologue 2 (EZH2) is a reliable immunohistochemical marker to differentiate malignant and benign hepatic tumors
por: Hajósi-Kalcakosz, Szofia, et al.
Publicado: (2012)

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance
por: Barbone, D, et al.
Publicado: (2011)

Apelin promotes lymphangiogenesis and lymph node metastasis
por: Berta, Judit, et al.
Publicado: (2014)

Expression of FGFR1–4 in Malignant Pleural Mesothelioma Tissue and Corresponding Cell Lines and its Relationship to Patient Survival and FGFR Inhibitor Sensitivity
por: Vlacic, Gregor, et al.
Publicado: (2019)

Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions
por: Priya, Rashmi, et al.
Publicado: (2017)

Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth
por: Buchberger, Elisabeth, et al.
Publicado: (2016)

Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma: an international multicenter study
por: Brcic, Luka, et al.
Publicado: (2021)

Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression
por: Barbone, Dario, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kj6ucmqmkqdq6gcpg8pnprdq0d