Calciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells

Dietary phosphate overload induces chronic kidney disease (CKD), and calciprotein particles (CPPs), a form of nanoparticle comprising calcium phosphate and serum proteins, has been proposed to cause renal toxicity. However, the mechanism of CPP cytotoxicity in renal tubular cells is unknown. Here we...

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Detalles Bibliográficos
Autores principales: Kunishige, Rina, Mizoguchi, Mai, Tsubouchi, Asako, Hanaoka, Kenjiro, Miura, Yutaka, Kurosu, Hiroshi, Urano, Yasuteru, Kuro-o, Makoto, Murata, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676272/
https://www.ncbi.nlm.nih.gov/pubmed/33208865
http://dx.doi.org/10.1038/s41598-020-77308-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676272/
https://www.ncbi.nlm.nih.gov/pubmed/33208865
http://dx.doi.org/10.1038/s41598-020-77308-3

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