Calciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells

Dietary phosphate overload induces chronic kidney disease (CKD), and calciprotein particles (CPPs), a form of nanoparticle comprising calcium phosphate and serum proteins, has been proposed to cause renal toxicity. However, the mechanism of CPP cytotoxicity in renal tubular cells is unknown. Here we...

Descripción completa

Detalles Bibliográficos
Autores principales: Kunishige, Rina, Mizoguchi, Mai, Tsubouchi, Asako, Hanaoka, Kenjiro, Miura, Yutaka, Kurosu, Hiroshi, Urano, Yasuteru, Kuro-o, Makoto, Murata, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676272/
https://www.ncbi.nlm.nih.gov/pubmed/33208865
http://dx.doi.org/10.1038/s41598-020-77308-3

Ejemplares similares

Ejemplares similares