Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice

Oxidative stress and neuronal apoptosis play crucial roles in secondary brain injury (SBI) after intracerebral hemorrhage (ICH). Recently, Nle4-D-Phe7-α-melanocyte-stimulating hormone (NDP-MSH), a synthetic agonist of the melanocortin-1 receptor (Mc1r), has been proved to inhibit neuroinflammatory i...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Siming, Luo, Xu, Wu, Xuan, Zhang, Tongyu, Gu, Linggui, Wang, Yiying, Gao, Meng, Cheng, Yuan, Xie, Zongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676969/
https://www.ncbi.nlm.nih.gov/pubmed/33274009
http://dx.doi.org/10.1155/2020/8864100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676969/
https://www.ncbi.nlm.nih.gov/pubmed/33274009
http://dx.doi.org/10.1155/2020/8864100

Ejemplares similares