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Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice

Oxidative stress and neuronal apoptosis play crucial roles in secondary brain injury (SBI) after intracerebral hemorrhage (ICH). Recently, Nle4-D-Phe7-α-melanocyte-stimulating hormone (NDP-MSH), a synthetic agonist of the melanocortin-1 receptor (Mc1r), has been proved to inhibit neuroinflammatory i...

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Detalles Bibliográficos
Autores principales:	Fu, Siming, Luo, Xu, Wu, Xuan, Zhang, Tongyu, Gu, Linggui, Wang, Yiying, Gao, Meng, Cheng, Yuan, Xie, Zongyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676969/ https://www.ncbi.nlm.nih.gov/pubmed/33274009 http://dx.doi.org/10.1155/2020/8864100

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