Synergistic Allostery in Multiligand-Protein Interactions

Amide hydrogen-deuterium exchange mass spectrometry is powerful for describing combinatorial coupling effects of a cooperative ligand pair binding at noncontiguous sites: adenosine at the ATP-pocket and a docking peptide (PIFtide) at the PIF-pocket, on a model protein kinase PDK1. Binding of two lig...

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Detalles Bibliográficos
Autores principales: Ghode, Abhijeet, Gross, Lissy Z.F., Tee, Wei-Ven, Guarnera, Enrico, Berezovsky, Igor N., Biondi, Ricardo M., Anand, Ganesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677135/
https://www.ncbi.nlm.nih.gov/pubmed/33086047
http://dx.doi.org/10.1016/j.bpj.2020.09.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677135/
https://www.ncbi.nlm.nih.gov/pubmed/33086047
http://dx.doi.org/10.1016/j.bpj.2020.09.019

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