Single cell mutation analysis of clonal evolution in myeloid malignancies

Myeloid malignancies, including acute myeloid leukemia (AML), arise from the expansion of hematopoietic stem/progenitor cells which acquire somatic mutations. Bulk molecular profiling suggests step-wise mutation acquisition, where mutant genes with high variant allele frequencies (VAFs) occur early...

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Detalles Bibliográficos
Autores principales: Miles, Linde A., Bowman, Robert L., Merlinsky, Tiffany R., Csete, Isabelle S., Ooi, Aik T., Durruthy-Durruthy, Robert, Bowman, Michael, Famulare, Christopher, Patel, Minal A., Mendez, Pedro, Ainali, Chrysanthi, Demaree, Benjamin, Delley, Cyrille L., Abate, Adam R., Manivannan, Manimozhi, Sahu, Sombeet, Goldberg, Aaron D., Bolton, Kelly L., Zehir, Ahmet, Rampal, Raajit, Carroll, Martin P., Meyer, Sara E., Viny, Aaron D., Levine, Ross L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677169/
https://www.ncbi.nlm.nih.gov/pubmed/33116311
http://dx.doi.org/10.1038/s41586-020-2864-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677169/
https://www.ncbi.nlm.nih.gov/pubmed/33116311
http://dx.doi.org/10.1038/s41586-020-2864-x

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