Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Fluoxazolevir is an aryloxazole-based entry inhibitor of hepatitis C virus (HCV). We show that fluoxazolevir inhibits fusion of HCV with hepatic cells by binding HCV envelope protein 1 (E1) to prevent fusion. 9 of 10 fluoxazolevir-resistance-associated substitutions are in the E1 protein and 4 are i...

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Detalles Bibliográficos
Autores principales: Ma, Christopher D., Imamura, Michio, Talley, Daniel C., Rolt, Adam, Xu, Xin, Wang, Amy Q., Le, Derek, Uchida, Takuro, Osawa, Mitsutaka, Teraoka, Yuji, Li, Kelin, Hu, Xin, Park, Seung Bum, Chalasani, Nishanth, Irvin, Parker H., Dulcey, Andres E., Southall, Noel, Marugan, Juan J., Hu, Zongyi, Chayama, Kazuaki, Frankowski, Kevin J., Liang, T. Jake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677215/
https://www.ncbi.nlm.nih.gov/pubmed/32868923
http://dx.doi.org/10.1038/s41564-020-0781-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677215/
https://www.ncbi.nlm.nih.gov/pubmed/32868923
http://dx.doi.org/10.1038/s41564-020-0781-2

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